Sofosbuvir is an antiviral drug used to treat Hepatitis C (HCV); it targets the virus’ NS5B protein, i.e. HCV’s RNA-dependent RNA polymerase (RdRp).

Affirmative evidence for SARS-CoV-2

Interactions (not exhaustive)

  • NICE UK:
    • H1 blockers (Cimetidine, Famotidine) decrease effects of Sofosbuvir.
  • Uni. of Alberta / DrugBank:
    • Acyclovir/Valaciclovir may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
    • Fexofenadine can increase the serum concentration of Sofosbuvir.

Similar drugs

  • AT-527
  • Tenofovir alafenamide
  • Remdesivir


Patient reviews